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Heparin - 5 Vials x 5 ml (5000 IU)

Heparin - 5 Vials x 5 ml (5000 IU)

Package: 5 Vials x 5 ml (5000 IU)

Usage: Injectable

It is used to stop blood clots forming within the blood vessels


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Brand names: Hep-Pak, Heparin Lock Flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage.
Generic Name: heparin (HEP a rin).

Heparin belongs to the medication groups known as anticoagulants. A question appears: which is the action of an anticoagulant? The function of anticoagulants is stopping coagulation; it means that anticoagulant stops blood from clotting. But anticoagulant can't diminish the size of the blood clots that have been already developed. It is necessary to notice that heparin has other functions too. The main purpose of this drug is to fight against invading bacteria and other foreign materials.
This preparation is administrated by injection into a vein or under the skin (subcutaneously). It must not be injected into a muscle.

Structure of Heparin
Heparin is composed of a differently sulfated repeating disaccharide unit. The most usual disaccharide unit is composed of a 2-O-sulfatediduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). For example, this makes up 85% of heparins from beef lung and about 75% of those from porcine intestinal mucosa.
The major sugars which occur in this drug are enumerated below:
α-L-iduronic acid 2-sulfate;
2-deoxy-2¬sulfamino-α-D-glucose 6-sulfate;
β-D-glucuronic acid;
2-acetamido-2-deoxy-α-D¬glucose;
α-L-iduronic acid.
The sugars listed above are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5). This medication is strongly acidic due to its content of covalently linked sulfate and carboxylic acid groups.

Mechanism of action of heparin
It has been already mentioned that this drug stops blood from clotting. How does it act? It neutralizes thrombin. In order to inactivate thrombin this medication links itself to the coagulation enzyme and antithrobin. The activated antithrombin neutralizes thrombin and other proteases involved in blood clotting. So, wee see that antithrombin suppresses coagulation by inactivating proteins that participate in the coagulation cascade.

Administration of Heparin
Heparin is used in case of dialysis, during extracorporeal circulation ardiopulmonary bypass for heart surgery.
This drug is utilized to treat patients with following illnesses:
peripheral occlusive disease;
thromboprophylaxis;
acute coronary syndrome;
atrial fibrillation;
deep-vein thrombosis and pulmonary embolism.

Heparin dosage
The prescribed dose of heparin depends on some aspects. The dose is henges on the coagulation test results. These tests must be done very often. The determination of coagulation time depends on certain factors. When heparin is administrated by continous intravenous infusion, the coagulation tests must be done approximately each four hours in the early stages of treatment. If the medicine is administered periodically by intravenous injection, coagulation tests must be done before each injection during the early stages of treatment.
In case of deep vein Thrombosis – Prophylaxis usual the recommended dose is 5000 units under the skin every 8 to 12 hours.
Usual dosage for anticoagulation during pregnancy is 5000 units under the skin every 12 hours.
Usual adult dosage for thrombotic disorder is100 units/mL each 6 to 8 hours for PVC catheters and peripheral heparin locks. But if stagnant blood is observed in catheter after it was utilized for drug or blood administration, it is necessary to add flushes. The dosage for babies that suffer of thrombotic disorder is 10 units every 6 to 8 hours. Child dosage in case mentioned above is 100 units/mL each 6 to 8 hours. Additional flushes should be administrated when stagnant blood is noticed in catheter, after catheter is used for drug or blood administration.
If a person has a massive pulmonary embolism, the starting dosage may be an IV bolus of 10,000 units which are followed by 1500 units per hour.

Possible negative reactions of heparin
Heparin, as every drug is able to cause unwanted consequences. Many people using this product do not have got serious undesirable consequences. Some general adverse consequences of this drug are following: swelling at injection site, bone pain, easily broken bones. Ache and lack of feeling in the arms and legs, change in color of the arms and legs, chest pain, difficult breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
Heparin may lead to some other negative consequences: signs of severe bleeding, including unusual ache, swelling, discomfort, long-term bleeding from cuts, continous nosebleeds, unusually heavy and long-term menstrual periods, unusual easy bruising, dark urine, black stools, severe headache, unusual dizziness.
Serious allergic reactions were reported rarely, but sometimes they can occur. If you utilize Heparin and notice such consequences as rash, itching, swelling, serious dizziness, difficult breathing and others, call your pharmacist.
There are such negative consequences that are caused in case of long-term Heparin using; others can be results of a systematic utilizing of this medicine. For example, osteoporosis can be caused by long-term utilizing of high dosages of this medication, cutaneous necrosis has been noticed after systemic utilizing; suppression of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on ceasing of this product have also been reported.
Important elevations of aminotransferase levels have occurred in a high percentage of patients and healthy subjects who have used this drug.

Coumadin and Heparin
Coumadin and Heparin are anticoagulants, so they both stop blood from clotting. They are utilized to cure such conditions as embolism and thrombosis. Even though they sound similar, coumadin and heparin have a lot of differences. As for utilizing them, coumadin is administrated orally, heparin is utilizedin a form of injection. Coumadin should not be used during pregnancy, heparin can be administrated by pregnant women. They both may cause excessive bleeding which may be life-threatening.

Heparin recall
Firstly, let notice what medicine recalls are. Medicine recalls are such actions that are done in order to remove some medications from the market.
As for Heparin, the most of recalls were in 2008 due to side effects of heparin which was produced in China.
But there were no any recalls related to heparin that was manufactured by B. Braun Medical Inc. B.Braun producer advices to stop heparin administration and contact your doctor, if any unwanted consequences occur.

Heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a form of thrombocytopenia that was developed as a result of utilizing of heparin. Thus, it is a undesirable consequence which was produced by heparin administration. There are two types of heparin-induced thrombocytopenia: type 1 and type 2. HIT type 2 is a more serious undesirable consequence than HIT type 2. HIT type 2 may be a fatal factor. In order to claim that a patient has HIT, he must do certain laboratory tests.

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